Compared to a person becoming hypertensive, somebody with an ideal BP is predicted to have a brain that appears more than 6 months younger at midlife.Įlevated blood pressure (BP) is a major health risk factor and a leading global cause for premature death ( Egan and Stevens-Fabry, 2015 Rahimi et al., 2015). These effects occurred across the blood pressure range and were not exclusively driven by hypertension.Ĭonclusion: Increasing blood pressure is associated with poorer brain health. In fully adjusted models, every additional 10 mmHg increase in blood pressure (above 90 for mean, 114 for systolic, and 74 for diastolic blood pressure) was associated with a higher BrainAGE by 65.7 days for mean, and 51.1 days for systolic/diastolic blood pressure. Results: A progressive increase in BP was observed over the follow up (MAP = 0.8 mmHg/year, SD = 0.92 SBP = 1.41 mmHg/year, SD = 1.49 DBP = 0.61 mmHg/year, SD = 0.78). Longitudinal associations between blood pressures and BrainAGE were assessed with linear mixed-effects models. Brain health was assessed using a machine learning approach to produce an estimate of “observed” age (BrainAGE), which can be contrasted with chronological age. Methods: Middle-age (44–46 years at baseline, n = 335, 52% female) and older-age (60–64 years, n = 351, 46% female) cognitively intact individuals underwent up to four brain scans. We addressed this gap by estimating how a validated measure of brain health relates to changes in BP over a period of 12 years. However, when elevated blood pressure starts impacting cerebral health is less clear. Hypertension is also a risk factor for cognitive decline and dementia.
8Department of Neurology, Jena University Hospital, Jena, Germany.7ANU Medical School, Australian National University, Canberra, ACT, Australia.6Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.5School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.4Neuroscience Research Australia, Sydney, NSW, Australia.3School of Psychology, University of Auckland, Auckland, New Zealand.2College of Engineering & Computer Science, Australian National University, Canberra, ACT, Australia.
1Centre for Research on Ageing, Health and Wellbeing, Australian National University, Canberra, ACT, Australia.Walsh 1, Marnie Shaw 2, Eileen Luders 1,3, Kaarin J.
0 kommentar(er)
